As 2025 comes to an end, it’s the perfect moment to reflect on what truly advanced longevity medicine this year — not in mice, not in theory, but in real humans. Here are the developments that meaningfully shape how we age going into 2026 and beyond. 1. Hormone Therapy for Women Was Finally Set Free On November 10, 2025, the FDA and HHS removed the long-standing boxed warning from many menopause-related hormone therapy products. For more than 20 years, this warning frightened

A recently released study has raised eyebrows in the medical community: long-term use of melatonin (3 - 10 mg in this study) was associated with a significantly increased risk of heart failure, hospitalizations, and even all-cause mortality in adults with chronic insomnia. While the study was observational (meaning it found an association, not causation), it’s still an important reminder of something I’ve seen repeatedly in my practice: melatonin is a hormone, not a vitamin,

For millions of women, hormone replacement therapy (HRT) was once a key part of vitality. But for more than two decades, fear has overshadowed its benefits, until now. November 10, 2025, marks a historic milestone in women’s health: the day the FDA officially removed the black box warning on hormone replacement therapy. This decision, now being referred to as “Menopause Liberation Day,”  signals a new era of science-based empowerment for women navigating midlife and beyond. A

Many of my patients know that I’m always looking for practical, evidence-based ways to reduce disease risk and extend healthy lifespan. One of the simplest tools for protecting your skin may already be sitting on the pharmacy shelf: vitamin B3 , also known as nicotinamide (or niacinamide ). A new study from Vanderbilt University Medical Center and the U.S. Veterans Affairs system looked at more than 33,000 veterans and found that those taking nicotinamide had a significantly