What a New Metformin Study Reveals About Aging Joints Osteoarthritis is often described as a simple consequence of aging, with joints wearing out, cartilage breaking down, and inevitable pain. But if osteoarthritis were purely a mechanical problem, we would expect it to progress at roughly the same pace in everyone. In reality, we see enormous variability. Some patients remain active and relatively pain free well into older age, while others develop significant joint pain and

Why many women are being told to stop hormones, and what modern evidence actually shows For many women, hormone therapy has felt confusing, or even frightening ever since large studies from more than 20 years ago raised concerns about its safety. Recently, several of my own patients told me they were advised during routine gynecologic visits to stop hormone therapy immediately due to fears of stroke, heart attack, blood clots, or cancer. That understandably created anxiety. T

Every January, people pause and reflect on where they are and where they want to go. Some call these resolutions. Others see them as a continuation of work they have already been doing for years. Either way, the new year creates a natural opportunity to recommit. Longevity is not built on motivation. It's built on repeatable systems that respect human physiology over decades, not weeks. Longevity Is Boring for a Reason When people hear that longevity work is "boring," they of

As we head into Christmas week, many of you are traveling, hosting family, or attending large gatherings. I want to briefly address the new circulating flu strain—commonly referred to in the media as the “K variant,” and medically classified as Influenza A (H3N2)—that we are seeing this season, and more importantly, what it means practically  for you and your family over the next 10 days. What’s different about this flu season? The term “K variant” refers to a subclade within

As 2025 comes to an end, it’s the perfect moment to reflect on what truly advanced longevity medicine this year — not in mice, not in theory, but in real humans. Here are the developments that meaningfully shape how we age going into 2026 and beyond. 1. Hormone Therapy for Women Was Finally Set Free On November 10, 2025, the FDA and HHS removed the long-standing boxed warning from many menopause-related hormone therapy products. For more than 20 years, this warning frightened

A recently released study has raised eyebrows in the medical community: long-term use of melatonin (3 - 10 mg in this study) was associated with a significantly increased risk of heart failure, hospitalizations, and even all-cause mortality in adults with chronic insomnia. While the study was observational (meaning it found an association, not causation), it’s still an important reminder of something I’ve seen repeatedly in my practice: melatonin is a hormone, not a vitamin,

For millions of women, hormone replacement therapy (HRT) was once a key part of vitality. But for more than two decades, fear has overshadowed its benefits, until now. November 10, 2025, marks a historic milestone in women’s health: the day the FDA officially removed the black box warning on hormone replacement therapy. This decision, now being referred to as “Menopause Liberation Day,”  signals a new era of science-based empowerment for women navigating midlife and beyond. A

Many of my patients know that I’m always looking for practical, evidence-based ways to reduce disease risk and extend healthy lifespan. One of the simplest tools for protecting your skin may already be sitting on the pharmacy shelf: vitamin B3 , also known as nicotinamide (or niacinamide ). A new study from Vanderbilt University Medical Center and the U.S. Veterans Affairs system looked at more than 33,000 veterans and found that those taking nicotinamide had a significantly

When BBC News recently reported on a blood test that can detect more than 50 types of cancer, it made global headlines. The Galleri test identifies subtle methylation patterns in circulating DNA fragments, the biological “whispers” that reveal the presence and origin of cancer long before imaging or symptoms appear. To many, this represents the future of medicine. To my patients, it’s already standard practice. For over two years, I’ve integrated Galleri into a deeper philoso

When most people think about hormones and aging, testosterone, estrogen, and maybe DHEA come to mind. But there’s another hormone that...

I’ve always focused on prevention, vitality, and optimizing health at every age. Today, I’m excited to announce that I’m now offering...

This morning, I had a realization that stopped me in my tracks. In Romanian, the common way to ask someone’s age is “Câți ani ai făcut?”...

This post is part of an ongoing series on how to grow stronger—not just older—with each birthday. If you missed the earlier parts of the...

Fasting has been practiced for centuries across cultures, valued for its profound health benefits. However, prolonged fasting can be...

In today's fast-paced world, optimizing your diet is one of the most effective ways to support longevity, maintain a healthy metabolism,...

This is the first in a series of blogs dedicated to extending your healthspan. In this series, we will dive deep into the key pillars of...